Allele specific gain-of-function activity of p53 mutants in lung cancer cells.

Abstract

p53 mutations are mostly single amino acid changes resulting in expression of a stable mutant protein with "gain of function" (GOF) activity having a dominant oncogenic role rather than simple loss of function of wild-type p53. Knock-down of mutant p53 in human lung cancer cell lines with different endogenous p53 mutants results in loss of GOF activity as… (More)
DOI: 10.1016/j.bbrc.2012.09.029

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