Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing.

@article{Neisig1996AllelespecificDI,
  title={Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing.},
  author={Anne Neisig and Richard W. Wubbolts and Xingxing Zang and Cornelis J. M. Melief and Jacques Neefjes},
  journal={Journal of immunology},
  year={1996},
  volume={156 9},
  pages={3196-206}
}
MHC class I molecules bind peptides that are translocated from the cytosol into the endoplasmic reticulum by the peptide transporter associated with antigen processing (TAP). Class I heterodimers have been shown to associate with TAP and are released when loaded with peptide. Here, we show the existence of two pools of class I heterodimers, one associated… CONTINUE READING