Allele-specific binding of the ubiquitous transcription factor OCT-1 to the functional single nucleotide polymorphism (SNP) sites in the tumor necrosis factor-alpha gene (TNFA) promoter

@article{Hohjoh2001AllelespecificBO,
  title={Allele-specific binding of the ubiquitous transcription factor OCT-1 to the functional single nucleotide polymorphism (SNP) sites in the tumor necrosis factor-alpha gene (TNFA) promoter},
  author={Hirohiko Hohjoh and Katsushi Tokunaga},
  journal={Genes and Immunity},
  year={2001},
  volume={2},
  pages={105-109}
}
The tumor necrosis factor-alpha gene (TNFA) is characterized by several single nucleotide polymorphisms (SNPs) in its promoter region. Interestingly, some of these SNPs appear to influence TNFA expression and susceptibility to various human diseases, but the molecular mechanisms by which such possibly functional SNPs modulate TNFA expression are poorly understood. In this study, we show allele-specific binding of the ubiquitous transcription factor OCT-1 to the SNP sites at positions −863 and… CONTINUE READING

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