Allele-specific activators and inhibitors for kinesin.

  title={Allele-specific activators and inhibitors for kinesin.},
  author={Tarun M Kapoor and Timothy J Mitchison},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 16},
Members of the kinesin superfamily are force-generating ATPases that drive movement and influence cytoskeleton organization in cells. Often, more than one kinesin is implicated in a cellular process, and many kinesins are proposed to have overlapping functions. By using conventional kinesin as a model system, we have developed an approach to activate or inhibit a specific kinesin allele in the presence of other similar motor proteins. Modified ATP analogs are described that do not activate… CONTINUE READING
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Kapoor and Mitchison Proc

  • Carson, M. Methods Enzymol. 277, 493–505. Cell Biology
  • Natl. Acad. Sci. USA 96
  • 1999

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