Allele-specific Hras mutations and genetic alterations at tumor susceptibility loci in skin carcinomas from interspecific hybrid mice.

@article{Nagase2003AllelespecificHM,
  title={Allele-specific Hras mutations and genetic alterations at tumor susceptibility loci in skin carcinomas from interspecific hybrid mice.},
  author={Hiroki Nagase and Jian-Hua Mao and Allan Balmain},
  journal={Cancer research},
  year={2003},
  volume={63 16},
  pages={4849-53}
}
We have investigated the effects of germ-line variants that influence skin tumor susceptibility loci on the patterns of somatic genetic alterations in mouse skin cancers. Using a two-stage skin carcinogenesis model, we previously identified at least 13 skin tumor susceptibility (Skts) loci in a large interspecific F1 backcross [(NIH/Ola x M. spretus) x NIH/Ola] study. In this report, we describe the analysis of allele-specific alterations at these loci in skin tumors from the same backcross… CONTINUE READING

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A subset of skin tumor modifier loci determines survival time of tumor-bearing mice.

Proceedings of the National Academy of Sciences of the United States of America • 1999
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