Allele-specific DNA methylation: beyond imprinting.

@article{Tycko2010AllelespecificDM,
  title={Allele-specific DNA methylation: beyond imprinting.},
  author={Benjamin Tycko},
  journal={Human molecular genetics},
  year={2010},
  volume={19 R2},
  pages={R210-20}
}
Allele-specific DNA methylation (ASM) and allele-specific gene expression (ASE) have long been studied in genomic imprinting and X chromosome inactivation. But these types of allelic asymmetries, along with allele-specific transcription factor binding (ASTF), have turned out to be far more pervasive-affecting many non-imprinted autosomal genes in normal human tissues. ASM, ASE and ASTF have now been mapped genome-wide by microarray-based methods and NextGen sequencing. Multiple studies agree… CONTINUE READING
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