Allele loss on chromosome 1p36 in epithelial ovarian cancers.

@article{Alvarez2001AlleleLO,
  title={Allele loss on chromosome 1p36 in epithelial ovarian cancers.},
  author={Angeles A. Alvarez and A R Lambers and Johnathan M. Lancaster and G Lawrence Maxwell and Shamshad Ali and Curtis E. Gumbs and Andrew Berchuck and Philip Andrew Futreal},
  journal={Gynecologic oncology},
  year={2001},
  volume={82 1},
  pages={94-8}
}
OBJECTIVES Prior studies have shown that allelic loss on chromosome 1p36 occurs frequently in ovarian as well as several other types of cancer. This suggests that inactivation of gene(s) in this region may play a role in the pathogenesis of these cancers. The aim of this study was to further delineate the region of loss on chromosome 1p36 in ovarian cancers and to identify associated patient or tumor characteristics. METHODS Paired normal/cancer DNA samples from 75 ovarian cancers (21 early… CONTINUE READING

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These findings further delineate regions on chromosome 1p36 proposed to contain tumor suppressor gene(s ) that may play a role in the development and/or progression of epithelial ovarian carcinoma .
These findings further delineate regions on chromosome 1p36 proposed to contain tumor suppressor gene(s ) that may play a role in the development and/or progression of epithelial ovarian carcinoma .
The aim of this study was to further delineate the region of loss on chromosome 1p36 in ovarian cancers and to identify associated patient or tumor characteristics . METHODS .
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