Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.

@article{Tsuda1990AlleleLO,
  title={Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.},
  author={Hitoshi Tsuda and Wan Dai Zhang and Yukio Shimosato and Jun Yokota and Masaaki Terada and Takashi Sugimura and Tatsuo Miyamura and Setsuo Hirohashi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1990},
  volume={87 17},
  pages={6791-4}
}
Loss of heterozygosity on chromosome 16 is a common genetic alteration in human hepatocellular carcinoma (HCC). To clarify the pathogenetic significance of allele loss on chromosome 16, we performed restriction fragment length polymorphism analysis of 70 surgically resected tumors by using 15 polymorphic DNA markers for chromosome 16. Loss of heterozygosity on chromosome 16 was detected in 36 (52%) of 69 informative cases, and the common region of allele loss in these 36 tumors was located… CONTINUE READING
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