Allele loss in Wilms tumors of chromosome arms 11q, 16q, and 22q correlate with clinicopathological parameters.

@article{Klamt1998AlleleLI,
  title={Allele loss in Wilms tumors of chromosome arms 11q, 16q, and 22q correlate with clinicopathological parameters.},
  author={Barbara Klamt and Markus Schulze and Claudia Th{\"a}te and Jaroslav Mare{\vs} and P. Goetz and R. Kodet and W. Scheulen and Angela Weirich and Norbert Graf and M. Gessler},
  journal={Genes, chromosomes & cancer},
  year={1998},
  volume={22 4},
  pages={
          287-94
        }
}
An extended analysis for loss of heterozygosity (LOH) on eight chromosomes was conducted in a series of 82 Wilms tumors. Observed rates of allele loss were: 9.5% (1p), 5% (4q), 6% (6p), 3% (7p), 9.8% (11q), 28% (11p15), 13.4% (16q), 8.8% (18p), and 13.8% (22q). Known regions of frequent allele loss on chromosome arms 1p, 11p15, and 16q were analyzed with a series of markers, but their size could not be narrowed down to smaller intervals, making any positional cloning effort difficult. In… CONTINUE READING

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