Allele loss from chromosome 17 in ovarian cancer.

@article{Russell1990AlleleLF,
  title={Allele loss from chromosome 17 in ovarian cancer.},
  author={S. E. Hilary Russell and G I Hickey and W. S. Lowry and Pat White and Richard C. Atkinson},
  journal={Oncogene},
  year={1990},
  volume={5 10},
  pages={1581-3}
}
In a number of human cancers genes capable of suppressing tumorigenicity have been identified and in some instances cloned. Successful isolation of such tumour suppressor genes has depended upon either the mapping of a locus which confers susceptibility to a specific tumour, or the finding of specific allele loss in the tumour cells of heterozygous individuals. In ovarian cancer it is known that a small proportion (approximately 5%) of tumours are due to inheritance (Lynch et al., 1989… CONTINUE READING

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