Allele frequencies of +874T --> A single nucleotide polymorphism at the first intron of IFN-gamma gene in Alzheimer's disease patients.

@article{Scola2003AlleleFO,
  title={Allele frequencies of +874T --> A single nucleotide polymorphism at the first intron of IFN-gamma gene in Alzheimer's disease patients.},
  author={Letizia Scola and Federico Licastro and Martina Chiappelli and Claudio Franceschi and Luigi Grimaldi and Antonio Crivello and Giuseppina Colonna-Romano and G Candore and Domenico Lio and Calogero Caruso},
  journal={Aging clinical and experimental research},
  year={2003},
  volume={15 4},
  pages={292-5}
}
BACKGROUND AND AIMS Inflammation seems to play a role in progressive neurological degenerative diseases such as Alzheimer's disease (AD). Local inflammatory processes can in fact give rise to direct neurotoxicity, interfere with beta-amyloid expression and metabolism, and maintain chronic, intracerebral, acute-phase protein secretion, in turn favoring the formation of beta-amyloid fibrils. Accordingly, recent studies show an increased risk for AD associated with certain polymorphisms in the… CONTINUE READING