Allele-dependent changes of olivocerebellar circuit properties in the absence of the voltage-gated potassium channels Kv3.1 and Kv3.3.

@article{McMahon2004AlleledependentCO,
  title={Allele-dependent changes of olivocerebellar circuit properties in the absence of the voltage-gated potassium channels Kv3.1 and Kv3.3.},
  author={Anne McMahon and Stephen J Fowler and Teresa M Perney and Walther Akemann and Thomas Kn{\"o}pfel and Rolf H. Joho},
  journal={The European journal of neuroscience},
  year={2004},
  volume={19 12},
  pages={3317-27}
}
Double-mutant mice (DKO) lacking the two voltage-gated K(+) channels Kv3.1 and Kv3.3 display a series of phenotypic alterations that include ataxia, myoclonus, tremor and alcohol hypersensitivity. The prominent cerebellar expression of mRNAs encoding Kv3.1 and Kv3.3 subunits raised the question as to whether altered electrical activity resulting from the lack of these K(+) channels might be related to the dramatic motor changes. We used the tremorogenic agent harmaline to probe mutant mice… CONTINUE READING

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