Allele-Specific Induction of IL-1 b Expression by C / EBP b and PU . 1 Contributes to Increased Tuberculosis Susceptibility

Abstract

Mycobacterium tuberculosis infection is associated with a spectrum of clinical outcomes, from long-term latent infection to different manifestations of progressive disease. Pro-inflammatory pathways, such as those controlled by IL-1b, have the contrasting potential both to prevent disease by restricting bacterial replication, and to promote disease by… (More)

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