Allele-Specific Induction of IL-1β Expression by C/EBPβ and PU.1 Contributes to Increased Tuberculosis Susceptibility

@inproceedings{Zhang2014AlleleSpecificIO,
  title={Allele-Specific Induction of IL-1β Expression by C/EBPβ and PU.1 Contributes to Increased Tuberculosis Susceptibility},
  author={Guoliang Zhang and Bo-ping Zhou and Shaoyuan Li and Jun Qin Yue and Hui Yang and Yuxin Wen and Senlin Zhan and Wen-fei Wang and Mingfeng Liao and Mingxia Zhang and Gucheng Zeng and Carl G Feng and Christopher M. Sassetti and Xinchun Chen and Thomas Richard Hawn},
  booktitle={PLoS pathogens},
  year={2014}
}
Mycobacterium tuberculosis infection is associated with a spectrum of clinical outcomes, from long-term latent infection to different manifestations of progressive disease. Pro-inflammatory pathways, such as those controlled by IL-1β, have the contrasting potential both to prevent disease by restricting bacterial replication, and to promote disease by inflicting tissue damage. Thus, the ultimate contribution of individual inflammatory pathways to the outcome of M. tuberculosis infection remains… CONTINUE READING