Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis

  title={Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis},
  author={Thomas LaFramboise and Barbara A. Weir and Xiaojun Zhao and Rameen Beroukhim and Cheng Li and David Harrington and William R. Sellers and Matthew Meyerson},
  journal={PLoS Computational Biology},
  pages={62 - 70}
Amplification, deletion, and loss of heterozygosity of genomic DNA are hallmarks of cancer. In recent years a variety of studies have emerged measuring total chromosomal copy number at increasingly high resolution. Similarly, loss-of-heterozygosity events have been finely mapped using high-throughput genotyping technologies. We have developed a probe-level allele-specific quantitation procedure that extracts both copy number and allelotype information from single nucleotide polymorphism (SNP… CONTINUE READING
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Genomic alterations in human lung carcinomas revealed by single nucleotide polymorphism (SNP) array analysis

  • X Zhao, BA Weir, T LaFramboise, M Lin, R Beroukhim
  • Cancer Res
  • 2005
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