All-trans-retinol generated by rhodopsin photobleaching induces rapid recruitment of TIP47 to lipid droplets in the retinal pigment epithelium.

@article{Tsuiki2007AlltransretinolGB,
  title={All-trans-retinol generated by rhodopsin photobleaching induces rapid recruitment of TIP47 to lipid droplets in the retinal pigment epithelium.},
  author={Eiko Tsuiki and Akikazu Fujita and Yuki Ohsaki and Jinglei Cheng and Toshiaki Irie and Kiwamu Yoshikawa and Haruki Senoo and Kazuaki Mishima and Takashi Kitaoka and Toyoshi Fujimoto},
  journal={Investigative ophthalmology \& visual science},
  year={2007},
  volume={48 6},
  pages={
          2858-67
        }
}
PURPOSE To investigate the effect of light stimulation on lipid droplets (LDs) and LD proteins in the retinal pigment epithelium (RPE). METHODS Dark-adapted mouse eyes were exposed to intense flashes of light, and ARPE-19 cells were treated with all-trans-retinol. The two specimens were labeled with BODIPY493/503 for LDs and with antibodies for three LD proteins: adipocyte differentiation-related protein (ADRP), TIP47, and Rab18. The labeling intensity in fluorescence microscopy was… 
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Retinyl Ester Homeostasis in the Adipose Differentiation-related Protein-deficient Retina*
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Observations suggest that Adfp plays a unique role in vision by maintaining proper storage and trafficking of retinoids within the eye by maintaining abnormal maintenance of RESTs in the dark-adapted state.
Retinal Pigment Epithelium-Retinal G Protein Receptor-Opsin Mediates Light-dependent Translocation of All-trans-retinyl Esters for Synthesis of Visual Chromophore in Retinal Pigment Epithelial Cells*
TLDR
The data establish that RPE cells are intrinsically sensitive to light and suggest that RGR-opsin mediates light-dependent translocation of all-trans-retinyl esters from a storage pool in lipid droplets to an “isomerase pool” in membranes of the endoplasmic reticulum to be utilized as substrate for the synthesis of a new visual chromophore.
Lipid Droplet Proteins and Hepatic Lipid Metabolism
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The current knowledge regarding expression and functions of each PLIN in the liver at physiological and pathological status is discussed.
The stellate cell system (vitamin A-storing cell system)
Past, present, and future research into hepatic stellate cells (HSCs, also called vitamin A-storing cells, lipocytes, interstitial cells, fat-storing cells, or Ito cells) are summarized and discussed…
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Four genes involved in receptor-mediated endocytosis have been identified, namely MRC1, CLEC4N, SORT1, and SCARF2, which represent possible new entities which may be relevant for macrophage lipoprotein handling.
PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores.
Perilipins: a diversity of intracellular lipid droplet proteins
TLDR
Current knowledge is summarized of the roles of perilipins and lipid metabolizing enzymes in a variety of mammalian cell types and that all play roles in LD function under differing conditions.
Uptake and storage of vitamin A as lipid droplets in the cytoplasm of cells in the lamina propria mucosae of the rat intestine
TLDR
The data suggest that these cells in the intestine could take up vitamin A from the systemic circulation and as well as by intestinal absorption, and store the vitamin in the lipid droplets in their cytoplasm.
Accumulation of Vitamin A in the Hepatic Stellate Cell of Arctic Top Predators
TLDR
It is suggested that HSCs have capacity to take‐up and store large amounts of vitamin A, which may play a pivotal role in maintenance of the food web, food chain, biodiversity, and eventually ecology of the arctic.
Biogenesis of cytoplasmic lipid droplets: from the lipid ester globule in the membrane to the visible structure.
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