All-trans-retinoid acid induces the differentiation of encapsulated mouse embryonic stem cells into GABAergic neurons.

@article{Addae2012AlltransretinoidAI,
  title={All-trans-retinoid acid induces the differentiation of encapsulated mouse embryonic stem cells into GABAergic neurons.},
  author={Cynthia Addae and Xiaoping Yi and Ramkishore Gernapudi and H Cheng and Alberto E. Musto and Eduardo Martinez-Ceballos},
  journal={Differentiation; research in biological diversity},
  year={2012},
  volume={83 5},
  pages={233-41}
}
Embryonic stem (ES) cells are pluripotent cells that can differentiate into all three main germ layers: endoderm, mesoderm, and ectoderm. Although a number of methods have been developed to differentiate ES cells into neuronal phenotypes such as sensory and motor neurons, the efficient generation of GABAergic interneurons from ES cells still presents an ongoing challenge. Because the main output of inhibitory GABAergic interneurons is the gamma-aminobutyric-acid (GABA), a neurotransmitter whose… CONTINUE READING

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