All-trans retinoic acid protects against arsenic-induced uterine toxicity in female Sprague-Dawley rats.


BACKGROUND AND PURPOSE Arsenic exposure frequently leads to reproductive failures by disrupting the rat uterine histology, hormonal integrity and estrogen signaling components of the rat uterus, possibly by generating reactive oxygen species. All-trans retinoic acid (ATRA) was assessed as a prospective therapeutic agent for reversing reproductive disorders… (More)
DOI: 10.1016/j.taap.2011.09.011