All-trans retinoic acid prevents development of cardiac remodeling in aortic banded rats by inhibiting the renin-angiotensin system.

@article{Choudhary2008AlltransRA,
  title={All-trans retinoic acid prevents development of cardiac remodeling in aortic banded rats by inhibiting the renin-angiotensin system.},
  author={Rashmi Choudhary and Ants Palm-Leis and R. C. Scott and Rakeshwar S. Guleria and Eric Rachut and Kenneth M. Baker and Jing Pan},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={294 2},
  pages={H633-44}
}
This study was designed to determine the effect of all-trans retinoic acid (RA) on the development of cardiac remodeling in a pressure overload rat model. Male Sprague-Dawley rats were subjected to sham operation and the aortic constriction procedure. A subgroup of sham control and aortic constricted rats were treated with RA for 5 mo after surgery. Pressure-overloaded rats showed significantly increased interstitial and perivascular fibrosis, heart weight-to-body weight ratio, and gene… CONTINUE READING

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