All-trans retinoic acid modulates bone morphogenic protein 9-induced osteogenesis and adipogenesis of preadipocytes through BMP/Smad and Wnt/β-catenin signaling pathways.

@article{Liu2014AlltransRA,
  title={All-trans retinoic acid modulates bone morphogenic protein 9-induced osteogenesis and adipogenesis of preadipocytes through BMP/Smad and Wnt/β-catenin signaling pathways.},
  author={Yang Liu and Yingzi Liu and Ranxi Zhang and Xing Wei Wang and Fan Yen Huang and Zhengjian Yan and Mao Nie and Jun Huang and Yuanzheng Wang and Yang Wang and Liang Chen and Liangjun Yin and Baicheng He and Zhongliang Deng},
  journal={The international journal of biochemistry & cell biology},
  year={2014},
  volume={47},
  pages={47-56}
}
It is known that excessive adipogenesis contributes to osteoporosis, suggesting that trans-differentiation of adipogenic committed preadipocytes into osteoblasts may be a potential therapeutical approach for osteoporosis. We explored whether bone morphogenic protein 9 (BMP9) could induce 3T3-L1 preadipocytes to trans-differentiate into osteoblasts. BMP9 effectively increased expression of osteogenic markers and promoted mineralization in preadipocytes. However, BMP9 also led to adipogenic… CONTINUE READING

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