All-trans retinoic acid is a ligand for the orphan nuclear receptor RORβ

@article{StehlinGaon2003AlltransRA,
  title={All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR$\beta$},
  author={Catherine Stehlin-Gaon and Dominica Willmann and Denis Zeyer and Sarah Sanglier and Alain Van Dorsselaer and Jean-Paul Renaud and Dino Moras and Roland Sch{\"u}le},
  journal={Nature Structural Biology},
  year={2003},
  volume={10},
  pages={820-825}
}
Retinoids regulate gene expression through binding to the nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs). In contrast, no ligands for the retinoic acid receptor–related orphan receptors β and γ (RORβ and γ) have been identified, yet structural data and structure-function analyses indicate that RORβ is a ligand-regulated nuclear receptor. Using nondenaturing mass spectrometry and scintillation proximity assays we found that all-trans retinoic acid (ATRA) and several… 
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