All-trans retinoic-acid inhibits heterodimeric bone morphogenetic protein 2/7-stimulated osteoclastogenesis, and resorption activity

@article{Bi2018AlltransRI,
  title={All-trans retinoic-acid inhibits heterodimeric bone morphogenetic protein 2/7-stimulated osteoclastogenesis, and resorption activity},
  author={Wen-juan Bi and Yi Liu and Jing Guo and Zhen Lin and Jinsong Liu and Miao Zhou and Daniel Wismeijer and Janak Lal Pathak and Gang Wu},
  journal={Cell \& Bioscience},
  year={2018},
  volume={8}
}
BackgroundBone regenerative heterodimeric bone morphogenetic protein 2/7 (BMP2/7) enhances but all-trans retinoic acid (ATRA) inhibits osteoclastogenesis. However, the effect of ATRA on physiological and/or BMP2/7-induced osteoclastogenesis in still unclear. In this study, we aimed to test the effect of combined treatment of BMP2/7 and ATRA on osteoclastogenesis, and resorption activity.ResultsAll-trans retinoic acid (1 µM) ± BMP2/7 (5 or 50 ng/ml) was added in murine pre-osteoclasts cell line… 
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1Jiangsu Hengshun Vinegar Industry Co., Ltd.,66 Hengshun Avenue, Dantu District, Zhenjiang 212143, China, 2School of Grain Science and Technology, Jiangsu University of Science and Technology,

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