All-trans-retinoic acid in maternal plasma and teratogenicity in rats and rabbits.

Abstract

The teratogenicity of all-trans-retinoic acid, 13-cis-retinoic acid, and retinol was investigated in pregnant Wistar rats given a single oral dose on Day 10 of gestation. External malformations showed dose-dependent increases and the order of potency was all-trans-retinoic acid > retinol > 13-cis-retinoic acid. The metabolites in maternal plasma were… (More)

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@article{Tembe1996AlltransretinoicAI, title={All-trans-retinoic acid in maternal plasma and teratogenicity in rats and rabbits.}, author={E. A. Tembe and Rice Honeywell and N E Buss and Andrew G. Renwick}, journal={Toxicology and applied pharmacology}, year={1996}, volume={141 2}, pages={456-72} }