All-trans retinoic acid enhances gap junctional intercellular communication among renal epithelial cells in vitro treated with renal carcinogens.

@article{Watanabe1999AlltransRA,
  title={All-trans retinoic acid enhances gap junctional intercellular communication among renal epithelial cells in vitro treated with renal carcinogens.},
  author={Jun Watanabe and Koichiro Nomata and Mitsuru Noguchi and Hironori Satoh and Shigeru Kanda and Hiroshi Kanetake and Yasushi Saito},
  journal={European journal of cancer},
  year={1999},
  volume={35 6},
  pages={
          1003-8
        }
}
Epidemiological and clinical studies imply that retinoids have a chemopreventative action against cancer and can suppress the growth of cancer cells. The regulation of connexin (Cx) expression by retinoids varies among tissues and organs. In this study, we investigated whether all-trans retinoic acid (ATRA) upregulates gap junctional intercellular communication (GJIC) in renal epithelial cells exposed to renal carcinogens. Madin Darby canine kidney (MDCK) cells were incubated with ATRA for 3… CONTINUE READING
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