All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination.

@article{Kusmartsev2003AlltransretinoicAE,
  title={All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination.},
  author={Sergei Kusmartsev and Fengdong Cheng and Bin Yu and Yulia Nefedova and Eduardo M. Sotomayor and Richard D. Lush and Dmitry Gabrilovich},
  journal={Cancer research},
  year={2003},
  volume={63 15},
  pages={4441-9}
}
Tumor-induced immunosuppression is one of the crucial mechanisms of tumor evasion of immune surveillance. It contributes greatly to the failure of cancer vaccines. Immature myeloid cells (ImCs) play an important role in tumor-induced immunosuppression. These cells accumulate in large numbers in tumor-bearing hosts and directly inhibit T-cell functions via… CONTINUE READING