All-trans-retinoic acid attenuates intestinal injury in a neonatal rat model of necrotizing enterocolitis.

@article{Ozdemir2013AlltransretinoicAA,
  title={All-trans-retinoic acid attenuates intestinal injury in a neonatal rat model of necrotizing enterocolitis.},
  author={Ramazan Ozdemir and Sadık Yurttutan and Fatma Nur Sari and Mehmet Yekta Oncel and Omer Erdeve and Hatice Germen Unverdi and B{\"u}lent Uysal and Uğur Dilmen},
  journal={Neonatology},
  year={2013},
  volume={104 1},
  pages={22-7}
}
BACKGROUND Ischemia/reperfusion-induced intestinal injury is mediated by reactive oxygen species and inflammatory mediators. OBJECTIVES This study was designed to evaluate whether all-trans-retinoic acid (ATRA) administration can attenuate intestinal injury and to analyze the antioxidant and anti-inflammatory effects of ATRA in a neonatal rat model of necrotizing enterocolitis (NEC). METHODS Twenty-nine Wistar albino rat pups were randomly divided into 3 groups: group 1 = control, group 2… CONTINUE READING