All-trans retinoic acid ameliorates trinitrobenzene sulfonic acid-induced colitis by shifting Th1 to Th2 profile.

@article{Bai2010AlltransRA,
  title={All-trans retinoic acid ameliorates trinitrobenzene sulfonic acid-induced colitis by shifting Th1 to Th2 profile.},
  author={Aiping Bai and Nonghua Lu and H. Zeng and Zhengrong Li and Xiaodong Zhou and Jiang Chen and Pi Liu and Zhikang Peng and Yuan Bo Guo},
  journal={Journal of interferon \& cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={2010},
  volume={30 6},
  pages={
          399-406
        }
}
  • A. Bai, N. Lu, +6 authors Y. Guo
  • Published 2010
  • Chemistry, Medicine
  • Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Inflammatory bowel disease is characterized with uncontrolled immune response in inflamed mucosa, with dominance of Th1 cells. Recently, all-trans retinoic acid has been shown that can lead T-cell response by suppressing Th17 development via retinoic acid receptor (RAR), but it is still unknown whether all-trans retinoic acid can modulate Th1 response of inflammatory bowel disease. In the experiment, we investigated the effect of all-trans retinoic acid on trinitrobenzene sulfonic acid (TNBS… Expand
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