All three ryanodine receptor isoforms generate rapid cooling responses in muscle cells.

@article{Protasi2004AllTR,
  title={All three ryanodine receptor isoforms generate rapid cooling responses in muscle cells.},
  author={Feliciano Protasi and Alexander Shtifman and Fred J. Julian and Paul D. Allen},
  journal={American journal of physiology. Cell physiology},
  year={2004},
  volume={286 3},
  pages={C662-70}
}
The rapid cooling (RC) response in muscle is an increase in cytoplasmic Ca2+ concentration ([Ca2+]i) that is probably caused by Ca2+ release from the sarcoplasmic reticulum (SR). However, the molecular bases of this response have not been completely elucidated. Three different isoforms of the SR Ca2+ release channels, or ryanodine receptors (RyRs), have been isolated (RyR1, RyR2, and RyR3). In the current investigation, the RC response was studied in RyR-null muscle cells (1B5) before and after… CONTINUE READING