All roads lead to the ribosome.

Abstract

In this issue of Cancer Cell, She et al. show that in cancer cells a protein called 4E-BP1 is a key integrator of protein synthesis downstream of the ERK and AKT signaling pathways, providing an intriguing rationale for why their simultaneous targeting could enhance therapeutic efficacy. 
DOI: 10.1016/j.ccr.2010.06.008

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