All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class

@article{CastilloGomez2017AllNO,
  title={All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class},
  author={Esther Castillo-Gomez and B{\'a}rbara Daniela Oliveira and Daniel Tapken and Sarah Bertrand and Christina Klein-Schmidt and Hong Pan and P Zafeiriou and Johann Steiner and Betty Jurek and Ralf Trippe and Harald Pr{\"u}ss and W-H Zimmermann and Denis Bertrand and Hannelore Ehrenreich and Michael Hollmann},
  journal={Molecular Psychiatry},
  year={2017},
  volume={22},
  pages={1776-1784}
}
Autoantibodies of the IgG class against N-methyl-d-aspartate-receptor subunit NR1 (NMDAR1) were first described in anti-NMDAR encephalitis and seen as disease indicators. Recent work on together over 5000 individuals challenged this exclusive view by showing age-dependently up to >20% NMDAR1-autoantibody seroprevalence with comparable immunoglobulin class and titer distribution across health and disease. The key question therefore is to understand the properties of these autoantibodies, also in… CONTINUE READING