All metacyclic variable antigen types of Trypanosoma congolense identified using monoclonal antibodies

@article{Crowe1983AllMV,
  title={All metacyclic variable antigen types of Trypanosoma congolense identified using monoclonal antibodies},
  author={J. S. Crowe and J. D. Barry and Antony George Luckins and Christopher A. Ross and Keith Vickerman},
  journal={Nature},
  year={1983},
  volume={306},
  pages={389-391}
}
Vaccination against the tsetse-borne trypanosomiases has proved impossible because of the trypanosome's ability to generate a seemingly inexhaustible number of variable antigen types in the blood or tissues of the host1. Each variable antigen is a glycoprotein which forms a surface coat on the trypanosome and each glycoprotein is the product of a single gene2,3. The full repertoire of such antigens has not been identified for any trypanosome serodeme (genotype) as yet, but the number of genes… CONTINUE READING