All is not well in the world of translational research.

  title={All is not well in the world of translational research.},
  author={Ellis F. Unger},
  journal={Journal of the American College of Cardiology},
  volume={50 8},
  • Ellis F. Unger
  • Published 2007 in Journal of the American College of Cardiology
It is not unusual for novel treatment strategies to fail in clinical trials, despite highly encouraging results in preclinical proof-of-concept studies. Typically, such "failures of translation" are blamed on the poor predictiveness of animal models. Often, however, the poor predictiveness of today's preclinical proof-of-concept studies is related not to limitations of the models but to investigator bias and a lack of scientific rigor. The resulting false-positive results only serve to mislead… CONTINUE READING

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