All indoleamine‐accumulating cells in the rabbit retina contain GABA

@article{Massey1992AllIC,
  title={All indoleamine‐accumulating cells in the rabbit retina contain GABA},
  author={Stephen C. Massey and Stephen L. Mills and Robert E. Marc},
  journal={Journal of Comparative Neurology},
  year={1992},
  volume={322}
}
The indoleamine‐accumulating amacrine cells of the rabbit retina are wide‐field and numerous. They form a dense plexus in sublamina 5 of the inner plexiform layer where they make reciprocal synapses with rod bipolar cells. To provide a quantitative test for the colocalization of serotonin (5‐HT) and γ‐aminobutyric acid (GABA) in the rabbit retina, we designed two parallel double‐label experiments. In the first series, the indoleamine‐accumulating cells were labeled with 5,7‐dihydroxytryptamine… 
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Catecholamine-, indoleamine-, and GABA-containing cells in the chameleon retina.
TLDR
The results confirmed those obtained in the retinas of other lizards except for the presence of interstitial and displaced amacrine cells containing TH or 5HT of which this is the first report.
Wide-field diffuse amacrine cells in the monkey retina contain immunoreactive Cocaine- and Amphetamine-Regulated Transcript (CART)
Immunocytochemical localization of the amino acid neurotransmitters in the chicken retina
Postembedding immunocytochemistry was used to determine the cellular localization of the amino acid neurotransmitters glutamate, aspartate, gamma‐aminobutyric acid (GABA), and glycine in the avian…
Coupling pattern of S1 and S2 amacrine cells in the rabbit retina
TLDR
The results suggest that the extensive coupling between S1 amacrine cells, combined with a larger dendritic field, may contribute a wide-field component to the inhibitory surround of the rod pathway, by comparison, the smaller, weakly coupled S2 amacine cells may provide a local component.
Feedback inhibition in the inner plexiform layer underlies the surround‐mediated responses of AII amacrine cells in the mammalian retina
TLDR
The results suggest that surround receptive fields of AII amacrine cells are generated indirectly by the GABAergic, reciprocal feedback synapses from S1/S2 amacine cells to the axon terminals of rod bipolar cells.
Development of neuropeptide Y immunoreactive amacrine and ganglion cells in the pre‐ and postnatal cat retina
TLDR
Interestingly, NPY expression within the ganglion cell population is temporally correlated with retinal synaptogenesis in the inner plexiform layer, and the prenatal presence of a regular distribution of NPY‐IR amacrine cells suggests that these cells may participate in establishing the gangLion cell mosaics that appear during postnatal development.
The relationship between GABA-containing cells and the cholinergic circuitry in the rabbit retina
TLDR
The results suggest that some GABAergic amacrine cells are cholinoceptive, raising the possibility that ACh, acting through nAChRs, can modulate the release of GABA in the rabbit retina.
Localization of GABAA receptors in the rabbit retina
The distribution of gamma-aminobutyric acidA (GABAA) receptors in the rabbit retina is investigated and compared with the distribution of GABAergic neurons using immunocytochemical methods.…
Surround inhibition of mammalian AII amacrine cells is generated in the proximal retina
TLDR
The results suggest that the on‐centre responses of AII cells result from the major excitatory drive from rod bipolar cells, however, the surround receptive fields of A II cells appear to be generated by lateral, inhibitory signals derived from neighbouring GABAergic, on-centre amacrine cells.
Antibody to calretinin stains AII amacrine cells in the rabbit retina: Double‐label and confocal analyses
TLDR
It is shown here that AII processes are adjacent to rod bipolar terminals at a level that far exceeds the random overlap present in images in which one label was rotated out of phase, and is indicative of synaptic connections.
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References

SHOWING 1-10 OF 65 REFERENCES
Connections of indoleamine‐accumulating cells in the rabbit retina
TLDR
These amacrine cells appear to exert an important effect on the transmission of scotopic information through the retina, as they exhibit large synaptic endings that occupy a substantial fraction of the surface of rod bipolar terminals.
A system of indoleamine-accumulating neurons in the rabbit retina
  • J. Sandell, R. Masland
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1986
TLDR
Using a new method in which the fluorescence of 5,7-DHT is photochemically converted to an insoluble diaminobenzidine product, an interrelated system of indoleamine-accumulating neurons of the rabbit retina was revealed.
Morphological and immunocytochemical identification of indoleamine- accumulating neurons in the cat retina
TLDR
The type and distribution of indoleamine-accumulating neurons were studied in the cat retina and it was revealed that the indoleamines- accumulating neurons comprise 2 distinct morphological types of amacrine cell and 1 class of ganglion cell.
Dopaminergic and indoleamine-accumulating amacrine cells express GABA- like immunoreactivity in the cat retina
  • H. Wassle, M. Chun
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1988
TLDR
Evidence is presented from colocalization studies for 2 types of interplexiform cell in the cat retina, which includes the dopaminergic amacrine cell, which also expresses GABA-like immunoreactivity, but does not accumulate 3H-muscimol.
Cholinergic amacrine cells of the rabbit retina contain glutamate decarboxylase and gamma-aminobutyrate immunoreactivity.
TLDR
It is established that cholinergic cells are a major subpopulation of GABA-immunoreactive amacrine and displacedAmacrine cells, and the role these cells have in the formation of ganglion cell receptive-field properties may be parsimoniously explained by an excitatory postsynaptic actionmediated by acetylcholine and an inhibitory presynaptic action mediated by GABA.
GABA‐ergic pathways in the goldfish retina
TLDR
A high‐affinity uptake mechanism for [3H]‐γ‐aminobutyric acid (GABA) has been localized to type H1 cone horizontal cells and type Ab pyriform amacrine cells in the retina of the goldfish by light and electron microscope autoradiography andSynaptic relations of apparently GABA‐ergic neurons were investigated in the electron microscope.
Indoleamine‐Sensitive Adenylate Cyclase in Rabbit Retina: Characterization and Distribution
TLDR
Cyclic AMP levels were measured in discrete retinal layers of both light‐ and dark‐adapted suprafused eyecups, and increased levels were observed primarily in the inner and outer plexiform layers, which contain the synapses of the retinal neurons.
Single cell shape and population densities of indoleamine-accumulating and displaced bipolar cells in Reeves' turtle retina
  • M. Tauchi
  • Biology
    Proceedings of the Royal Society of London. B. Biological Sciences
  • 1990
TLDR
Close examination of many cells showed that the IA bipolar cells consist of a single morphological type whose axon collaterals ramify sublaminae 1, 4 and 5 respectively, which corresponds to cells that hyperpolarize when their receptive field centres are illuminated.
Serotonin Levels in the Rabbit Retina Are Elevated Following Intraocular Injection of Forskolin
Abstract: Analysis of the mammalian retina for serotonin irnmu‐noreactivity suggests an absence of the amine. However, following an intraocular injection of forskolin (1 μM) into a rabbit eye 1 h…
Morphological identification of serotonin-accumulating neurons in the living retina.
TLDR
It is revealed that the serotonin-accumulating neurons in rabbit retina constitute two morphological types of amacrine cells, termed S1 and S2, whose distal dendrites are stratified at the inner margin of the inner plexiform layer.
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