All in one: Leishmania major STT3 proteins substitute for the whole oligosaccharyltransferase complex in Saccharomyces cerevisiae.

@article{Nasab2008AllIO,
  title={All in one: Leishmania major STT3 proteins substitute for the whole oligosaccharyltransferase complex in Saccharomyces cerevisiae.},
  author={Farnoush Parsaie Nasab and Benjamin L Schulz and Francisco Gamarro and Armando J. Parodi and Markus Aebi},
  journal={Molecular biology of the cell},
  year={2008},
  volume={19 9},
  pages={
          3758-68
        }
}
The transfer of lipid-linked oligosaccharide to asparagine residues of polypeptide chains is catalyzed by oligosaccharyltransferase (OTase). In most eukaryotes, OTase is a hetero-oligomeric complex composed of eight different proteins, in which the STT3 component is believed to be the catalytic subunit. In the parasitic protozoa Leishmania major, four STT3 paralogues, but no homologues to the other OTase components seem to be encoded in the genome. We expressed each of the four L. major STT3… CONTINUE READING

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