The aim of the study was to investigate whether the properties of a pre-sintered, hot isostatic post-compacted (HIP) ZrO2 are adequate for use in three-five-unit fixed partial dentures (FPDs) and to evaluate the clinical results. Twenty three-five-unit FPDs were fabricated for 18 patients on a total of 56 abutments. They were all made on abutments cut with a shoulder preparation and cemented with a zinc phosphate cement. They were clinically followed for 24 months. After 24 months all FPDs were still in use without any fractures or clinical wear but in three cases (15%) minor chip-of fractures were observed. Marginal integrity was rated excellent at 45 abutments and acceptable at 11. Within the limitations of this 2-year clinical follow-up study, FPDs made of pre-sintered HIP ZrO2 core material veneered with a compatible ceramic is an acceptable alternative in the fabrication of FPDs with the extensions investigated in this study. Special attention, however, must be paid to designing the core for an occlusal shape that provides sufficient support for the veneer.