All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor.

@article{Margolis1989AllAS,
  title={All autophosphorylation sites of epidermal growth factor (EGF) receptor and HER2/neu are located in their carboxyl-terminal tails. Identification of a novel site in EGF receptor.},
  author={Bernardo Margolis and Irit Lax and Richard Kris and M J Dombalagian and Adrian Honegger and R S Howk and David Givol and Axel Ullrich and Joseph Schlessinger},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 18},
  pages={10667-71}
}
Activation of the epidermal growth factor (EGF) receptor kinase leads to autophosphorylation and to the phosphorylation of various cellular substrates. The three known autophosphorylation sites of EGF receptor are located at the carboxyl-terminal tail where they probably act to compete with and thus modulate substrate phosphorylation. Mutational analysis and microsequencing techniques have been used to localize and identify new autophosphorylation site(s) of the EGF receptor. We have compared… CONTINUE READING

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