All-atom ensemble modeling to analyze small-angle x-ray scattering of glycosylated proteins.

@article{Guttman2013AllatomEM,
  title={All-atom ensemble modeling to analyze small-angle x-ray scattering of glycosylated proteins.},
  author={Miklos Guttman and Patrick Weinkam and Andrej Sali and Kelly K. Lee},
  journal={Structure},
  year={2013},
  volume={21 3},
  pages={321-31}
}
The flexible and heterogeneous nature of carbohydrate chains often renders glycoproteins refractory to traditional structure determination methods. Small-angle X-ray scattering (SAXS) can be a useful tool for obtaining structural information of these systems. All-atom modeling of glycoproteins with flexible glycan chains was applied to interpret the solution SAXS data for a set of glycoproteins. For simpler systems (single glycan, with a well-defined protein structure), all-atom modeling… CONTINUE READING

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