All-Trans Retinoic Acid Reverses Phorbol Ester Resistance

Abstract

Treatment of human HL-60 leukemic cells with 12-0-tetradecanoylphorbol-13-acetate (TPA) is associated with activation of protein kinase C (PKC) and induction of monocytic differentiation. An HL-60 variant cell line, termed HL525, derived from long-term exposure to TPA (Homma et al. Proc Natl Acad Sci USA 83:7316, 1986) is resistant to TPA-induced… (More)

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@inproceedings{Yang2002AllTransRA, title={All-Trans Retinoic Acid Reverses Phorbol Ester Resistance}, author={Kuender D. Yang and Tokihide Mizobuchi and Surender M. Kharbanda and Rakesh Datta and Eliezer Huberman and Donald Kufe}, year={2002} }