All-Trans Retinoic Acid Inhibits Human Colorectal Cancer Cells RKO Migration via Downregulating Myosin Light Chain Kinase Expression through MAPK Signaling Pathway.

@article{Zuo2016AllTransRA,
  title={All-Trans Retinoic Acid Inhibits Human Colorectal Cancer Cells RKO Migration via Downregulating Myosin Light Chain Kinase Expression through MAPK Signaling Pathway.},
  author={Li Zuo and Xiaoping Yang and Man Lu and Ruolei Hu and Huaqing Zhu and Sumei Zhang and Qing Zhou and Fei-hu Chen and Shuyu Gui and Yuan Wang},
  journal={Nutrition and cancer},
  year={2016},
  volume={68 7},
  pages={1225-33}
}
All-trans-retinoic acid (ATRA) inhibits the invasive and metastatic potentials of various cancer cells. However, the underlying mechanism is unclear. Here, we demonstrate that ATRA inhibited colorectal cancer cells RKO (human colon adenocarcinoma cell) migration by downregulating cell movement and increasing cell adhesion. ATRA inhibited the expression and… CONTINUE READING