All JNKs can kill, but nuclear localization is critical for neuronal death.

  title={All JNKs can kill, but nuclear localization is critical for neuronal death.},
  author={Benny Bj{\"o}rkblom and Jenni C Vainio and Vesa Hongisto and Thomas Herdegen and Michael J Courtney and Eleanor T. Coffey},
  journal={The Journal of biological chemistry},
  volume={283 28},
JNKs are implicated in a range of brain pathologies and receive considerable attention as potential therapeutic targets. However, JNKs also regulate physiological and homeostatic processes. An attractive hypothesis from the drug development perspective is that distinct JNK isoforms mediate "physiological" and "pathological" responses. However, this lacks experimental evaluation. Here we investigate the isoforms, subcellular pools, and c-Jun/ATF2 targets of JNK in death of central nervous system… CONTINUE READING


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