Alkynylation of cyclopropyl trifluoromethyl ketone catalyzed by CuF2·2H2O/4,7-diphenyl-1,10-phenanthroline

  title={Alkynylation of cyclopropyl trifluoromethyl ketone catalyzed by CuF2·2H2O/4,7-diphenyl-1,10-phenanthroline},
  author={Xiao-dong Liu and Hai-yan Ma and Chunhui Xing and Long Lu},
Abstract CuF 2 ·2H 2 O/4,7-diphenyl-1,10-phenanthroline was found to be a highly efficient catalyst for the nucleophilic alkynylation of cyclopropyl trifluoromethyl ketone. The corresponding trifluoromethyl-substituted tertiary propargyl alcohols were synthesized in moderate to excellent yields under mild conditions. The catalyst system could also be applied to aromatic trifluoromethyl ketone as well as trifluoropyruvate.