Alkyltransferase transgenic mice: probes of chemical carcinogenesis.

@article{Gerson1994AlkyltransferaseTM,
  title={Alkyltransferase transgenic mice: probes of chemical carcinogenesis.},
  author={Stanton L. Gerson and Neelam Hazoor Zaidi and Luba L. Dumenco and Esther R. Allay and Chun Yang Fan and Lihua Liu and Peter J. O'connor},
  journal={Mutation research},
  year={1994},
  volume={307 2},
  pages={
          541-55
        }
}
Transgenic mice expressing DNA-repair genes are an instructive model with which to study the protective role of DNA-repair pathways in both spontaneous and chemical carcinogenesis. Of particular interest in chemical carcinogenesis is the DNA-repair protein O6-alkylguanine-DNA alkyltransferase (alkyltransferase) which repairs O6-alkylguanine-DNA adducts. Transgenic mice carrying expression constructs for the alkyltransferase gene--either the human MGMT cDNA or the bacterial ada gene--express… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-7 OF 7 CITATIONS

Advances in Nutrition and Cancer 2

  • Advances in Experimental Medicine and Biology
  • 1999

Quantitative immunohistochemical estimates of O6-alkylguanine-DNA alkyltransferase expression in normal and malignant human colon.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 1996
VIEW 1 EXCERPT
CITES BACKGROUND