Alkylthioacetic acids (3-thia fatty acids) are metabolized and excreted as shortened dicarboxylic acids in vivo.

@article{Bergseth1990AlkylthioaceticA,
  title={Alkylthioacetic acids (3-thia fatty acids) are metabolized and excreted as shortened dicarboxylic acids in vivo.},
  author={S. Bergseth and J. Bremer},
  journal={Biochimica et biophysica acta},
  year={1990},
  volume={1044 2},
  pages={
          237-42
        }
}
  • S. Bergseth, J. Bremer
  • Published 1990
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • The metabolism of 1-14C-labeled long-chain alkylthioacetic acids (3-thia fatty acids) which are blocked for normal beta-oxidation by a sulfur atom in the beta-position has been investigated in vivo. Most of the injected radioactivity (greater than 50%) was excreted in the urine within the first 48 h. The recovered and identified metabolites were all short sulfoxydicarboxylic acids. The main metabolite from dodecylthioacetic acid was carboxypropylsulfoxy acetic acid. Some bis(carboxymethyl… CONTINUE READING
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