Alkylphosphocholines: a new class of membrane-active anticancer agents

Abstract

From the foregoing it is evident that the experimental profile of miltefosine and alkylphosphocholines is different from that of conventional anticancer agents. Much evidence indicated that the mode of action of alkylphosphocholines was related to plasma-membrane-associated phosphoinositide metabolism. Inhibition of phospholipase C and/or PKC is currently… (More)
DOI: 10.1007/BF00685608

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