Alkylbenzoquinone involved in development of cellular slime molds.

  title={Alkylbenzoquinone involved in development of cellular slime molds.},
  author={Yoshiaki Takaya and Rie Hotta and Kenshu Fujiwara and Risa Otani and Yurika Uchiyama and Mizuki Sakakibara and Eri Fukuda and Masatake Niwa and Kei Inouye and Akiko A. Oohata},
  journal={Organic letters},
  volume={16 14},
  • Yoshiaki Takaya, Rie Hotta, +7 authors Akiko A. Oohata
  • Published in Organic letters 2014
  • Medicine, Chemistry
  • The structure of the prespore-cell-promoting factor from Dictyostelium discoideum was determined to be 2-hydroxy-5-methyl-6-pentylbenzoquinone. The synthetic compound has prespore-cell-promoting activity similar to the natural one, with half-maximal induction at a concentration as low as 40 pM. It was also found that the factor induces aggregation in an aggregation-deficient mutant of a related species, Polysphodilium violaceum. Both these activities are sensitive to positional isomerism with… CONTINUE READING

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