Alkylation of DNA and hemoglobin in the mouse following exposure to ethene and ethene oxide.

@article{Segerbck1983AlkylationOD,
  title={Alkylation of DNA and hemoglobin in the mouse following exposure to ethene and ethene oxide.},
  author={Dan Segerb{\"a}ck},
  journal={Chemico-biological interactions},
  year={1983},
  volume={45 2},
  pages={
          139-51
        }
}
Exposure of mice to 14C-labelled ethene or ethene oxide gave rise to hydroxyethylations of nucleophilic sites in hemoglobin and DNA. The relative amounts of alkylation products of different amino acids in hemoglobin were the same for the two compounds. Furthermore, the ratio between the degree of alkylation of DNA in various organs and of hemoglobin was approximately the same, supporting a previous conclusion that ethene oxide is the reactive intermediate formed in vivo from ethene. A… CONTINUE READING
BETA

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 41 CITATIONS

Similar Papers

Loading similar papers…