Alkylating properties of phosphoramide mustard.

@article{Colvin1976AlkylatingPO,
  title={Alkylating properties of phosphoramide mustard.},
  author={M. Alex Colvin and Robert B. Brundrett and Matsubara Kan and Ian David Jardine and Catherine Fenselau},
  journal={Cancer research},
  year={1976},
  volume={36 3},
  pages={
          1121-6
        }
}
The relative alkylating activities of two of the cytotoxic metabolites of cyclophosphamide, phosphoramide mustard and nornitrogen mustard, have been studied at pH 4.6 and 7.4. The products formed on alkylation of ethanethiol by these metabolites have been identified, confirming that phosphoramide mustard undergoes alkylation reactions as an intact molecule. Deuterated analogs of the two metabolites have been synthesized, namely N,N-bis(2,2-dideutero-2-chloroethyl)-phosphorodiamidic acid and N,N… CONTINUE READING

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