Alkylating HIV-1 Nef - a potential way of HIV intervention

@article{Jin2010AlkylatingHN,
  title={Alkylating HIV-1 Nef - a potential way of HIV intervention},
  author={Yongjiu Jin and Xiaoping Zhang and C. Y. Cai and S. Burakoff},
  journal={AIDS Research and Therapy},
  year={2010},
  volume={7},
  pages={26 - 26}
}
BackgroundNef is a 27 KDa HIV-1 accessory protein. It downregulates CD4 from infected cell surface, a mechanism critical for efficient viral replication and pathogenicity. Agents that antagonize the Nef-mediated CD4 downregulation may offer a new class of drug to combat HIV infection and disease. TPCK (N-α-p-tosyl-L-phenylalanine chloromethyl ketone) and TLCK (N-α-p-tosyl-L-lysine chloromethyl ketone) are alkylation reagents that chemically modify the side chain of His or Cys residues in a… Expand
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