Alkylated resveratrol prodrugs and metabolites as potential therapeutics for neurodegenerative diseases.

@article{Pealver2018AlkylatedRP,
  title={Alkylated resveratrol prodrugs and metabolites as potential therapeutics for neurodegenerative diseases.},
  author={Pablo Pe{\~n}alver and Efres Belmonte-Reche and Norma Ad{\'a}n and M P Garc{\'i}a Caro and Mar{\'i}a Luisa Mateos-Mart{\'i}n and Mario Delgado and Elena Gonz{\'a}lez-Rey and Juan Carlos Morales},
  journal={European journal of medicinal chemistry},
  year={2018},
  volume={146},
  pages={123-138}
}
Resveratrol is a naturally occurring stilbene which has shown promising results as treatment for several neurodegenerative diseases. However, its application is limited due to its low efficacy and bioavailability. Here, we have designed and synthesized alkylated resveratrol prodrugs combining structural modification to improve antioxidant and anti… CONTINUE READING