Alkylated porphyrins have broad antiviral activity against hepadnaviruses, flaviviruses, filoviruses, and arenaviruses.

@article{Guo2011AlkylatedPH,
  title={Alkylated porphyrins have broad antiviral activity against hepadnaviruses, flaviviruses, filoviruses, and arenaviruses.},
  author={Haitao Guo and Xiaoben Pan and Richeng Mao and Xianchao Zhang and Lijuan Wang and Xuanyong Lu and Jinhong Chang and Ju-Tao Guo and Shendra R Passic and Fred C Krebs and Brian Wigdahl and Travis Warren and Cary J. Retterer and Sina Bavari and Xiaodong Xu and Andrea Cuconati and Timothy M. Block},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 2},
  pages={478-86}
}
We screened ∼2,200 compounds known to be safe in people for the ability to reduce the amount of virion-associated hepatitis B virus (HBV) DNA in the culture medium of producer cells. These efforts led to the discovery of an alkylated porphyrin, chlorophyllide, as the compound that achieved the greatest reduction in signal. Here we report that chlorophyllide directly and quantitatively disrupted HBV virions at micromolar concentrations, resulting in the loss of all detectable virion DNA, without… CONTINUE READING
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